ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Bone Miner Res. 2020;35(2):248–260.In brief: This randomized open-label trial in oligoamenorrheic athletes evaluated the effects of transdermal estrogen, oral estrogen or no replacement on bone metabolism, geometry, and microarchitecture. Transdermal estrogen treatment resulted in significantly greater increases in volumetric bone mineral d...

To read the full abstract: J Clin Invest 2019;129:5187–5203.In brief: This report establishes inhibition of salt-inducible kinases as a central mechanism by which the parathyroid hormone 1 receptor (PTH1R) exerts its effects in both growth plate chondrocytes and osteoblasts/osteocytes during skeletal development, growth, and remodelling.Commentary</e...

To read the full abstract: Cell. 2018 Dec 13;175(7):1756–1768.e17.Irisin, a cytokine secreted by muscle during exercise, effects bone resorption and the differentiation of preadipocytes into thermogenic brown fat cells by displacing tethers between the cell and extracellular matrix molecules. Physical activity can reverse age-dependent decline in skeletal muscle, preventing osteopor...